9NCD

Crystal structure of the peanut allergen Ara h 9 with bound Fab IGX-3103 and antiFab nanobody

9NCD の概要

• エントリーDOI: 10.2210/pdb9ncd/pdb
• 分子名称: Fab IGX-3103 light chain, Fab IGX-3103 heavy chain, anti Kappa light chain nanobody (antiFab), ... (9 entities in total)
• 機能のキーワード: allergy, antibody complex, peanut, allergen
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95907.49

構造登録者

Pedersen, L.C.,Mueller, G.A. (登録日: 2025-02-15, 公開日: 2026-02-18)

主引用文献

Leighton, G.O.,Pedersen, L.C.,Min, J.,Creeks, P.,Gabel, S.A.,Perera, L.,Randall, T.A.,Petrovich, R.M.,Hamilton, R.G.,Croote, D.,Mueller, G.A.
A Human Monoclonal Antibody Displays Promiscuous Binding to Multiple Type 1 nsLTP Allergens.
J Investig Allergol Clin Immunol, :0-0, 2026

PubMed Abstract: Nonspecific lipid transfer proteins (nsLTPs) are frequently cross-reactive allergens that hamper diagnosis and avoidance. It is challenging to distinguish cross-reactivity from cosensitization with polyclonal serum owing to the presence of a few promiscuous antibodies or many highly specific antibodies. Objective: We hypothesized that a robust analysis of more human monoclonal antibodies (mAbs) would enable us to compare crossreactivity with cosensitization.

PubMed: 41661651
DOI: 10.18176/jiaci.1143

実験手法

X-RAY DIFFRACTION (1.6 Å)