9N36

CryoEM structure Of Respiratory Syncytial Virus Polymerase with novel non-nucleoside inhibitor compound 22

This is a non-PDB format compatible entry.

Summary for 9N36

• Entry DOI: 10.2210/pdb9n36/pdb
• EMDB information: 48846
• Descriptor: RNA-directed RNA polymerase L, Phosphoprotein, 5-(5-bromo-1-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidin]-1'-yl)-3-chloropyridine-2-carbonitrile (3 entities in total)
• Functional Keywords: non-nucleoside inhibitor, complex, polymerase, rsv, viral protein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: human respiratory syncytial virus; More
• Total number of polymer chains: 5
• Total formula weight: 371045.84

Authors

Yin, Y.,Yu, X.,Kalin, J.H.,Tran, M.T.,Sharma, S. (deposition date: 2025-01-30, release date: 2025-05-28)

• Primary citation: Yin, Y.,Yu, X.,Kalin, J.H.,Tran, M.T.,Sujata, S.; CryoEM structure Of Respiratory Syncytial Virus Polymerase in complex with novel non-nucleoside inhibitor 5-(5-bromo-1-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidin]-1'-yl)-3-chloropyridine-2-carbonitrile (compound 22); To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.72 Å)