9MW4

Co-crystal structure of feline coronavirus UU23 main protease with Pfizer intravenous compound PF-00835231

Summary for 9MW4

• Entry DOI: 10.2210/pdb9mw4/pdb
• Descriptor: ORF1ab polyprotein, N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, ACETIC ACID, ... (7 entities in total)
• Functional Keywords: mpro, uu23, feline coronavirus, viral protein, main protease, pf-00835231, feline enteric coronavirus, alpha coronavirus
• Biological source: Feline alphacoronavirus 1
• Total number of polymer chains: 1
• Total formula weight: 34336.92

Authors

Shaqra, A.M.,Maryam, A.,Schiffer, C.A. (deposition date: 2025-01-16, release date: 2025-11-26)

• Primary citation: Maryam, A.,Moquin, S.A.,Dovala, D.,Kaur, J.,Kurt Yilmaz, N.,Shaqra, A.M.,Schiffer, C.A.; Structural Analysis of Inhibitor Binding to the Feline Enteric Coronavirus (FECV) Main Protease; Viruses, 17:-, 2025; DOI: 10.3390/v17111506

Experimental method

X-RAY DIFFRACTION (1.5 Å)