9MUC

Human IMPDH2 mutant - S160del, treated with GTP, ATP, IMP, and NAD+; interfacial octamer reconstruction

Summary for 9MUC

• Entry DOI: 10.2210/pdb9muc/pdb
• Related: 9MUB
• EMDB information: 48627 48628
• Descriptor: Inosine-5'-monophosphate dehydrogenase 2, INOSINIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• Functional Keywords: dehydrogenase, purine biosynthesis, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 459240.42

Authors

O'Neill, A.G.,Kollman, J.M. (deposition date: 2025-01-13, release date: 2025-12-03)

• Primary citation: O'Neill, A.G.,McCartney, M.E.,Wheeler, G.M.,Patel, J.H.,Kollman, J.M.,Wills, A.E.; Overexpression of pathogenic human IMPDH2 variant in Xenopus tropicalis disrupts somitogenesis; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.1 Å)