9MT8

Cryo-EM structure of the human TRPM4 channel in a calcium bound putative desensitized state

Summary for 9MT8

• Entry DOI: 10.2210/pdb9mt8/pdb
• Related: 9MRT
• EMDB information: 48563 48603
• Descriptor: Transient receptor potential cation channel subfamily M member 4, CALCIUM ION (2 entities in total)
• Functional Keywords: trpm4, ion channel, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 537986.25

Authors

Teixeira-Duarte, C.M.,Jiang, Y. (deposition date: 2025-01-10, release date: 2025-10-29)

• Primary citation: Teixeira-Duarte, C.M.,Zeng, W.,Jiang, Y.; Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel; Nat.Struct.Mol.Biol., 2025; DOI: 10.1038/s41594-025-01705-3

Experimental method

ELECTRON MICROSCOPY (3.19 Å)