9M6P

Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation

This is a non-PDB format compatible entry.

Summary for 9M6P

• Entry DOI: 10.2210/pdb9m6p/pdb
• Descriptor: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 2,4-dimethyl-3-[2-(2-methylpyrimidin-5-yl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]phenol, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: pkmyt1, inhibitor, crystal, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 69882.43

Authors

Yazhou, W.,Chao, W. (deposition date: 2025-03-07, release date: 2025-11-05)

• Primary citation: Wang, Y.,Ding, X.; Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation; Nat Commun, 2025; DOI: 10.1038/s41467-025-65796-8

Experimental method

X-RAY DIFFRACTION (2.383 Å)