9LWP

Cryo-EM structure of the unliganded human BRS3-Gq complex

Summary for 9LWP

Entry DOI	10.2210/pdb9lwp/pdb
EMDB information	63455
Descriptor	Bombesin receptor subtype-3,Oplophorus-luciferin 2-monooxygenase catalytic subunit, Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (4 entities in total)
Functional Keywords	unliganded, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	141187.83
Authors	Li, J.,Li, C.,Zhou, Q.,Han, W.,Fang, M.,Xu, Y.,Mai, Y.,Cui, J.,Xu, H.,Zhang, Y.,Wang, M. (deposition date: 2025-02-16, release date: 2025-07-16)
Primary citation	Li, J.,Li, C.,Zhou, Q.,Han, W.,Fang, M.,Xu, Y.,Mai, Y.,Zhang, Y.,Cui, J.,Xu, H.E.,Zhang, Y.,Yin, W.,Wang, M.W. Divergent activation patterns of BRS3 revealed by two Chinese herb-derived agonists Acta Pharm Sin B, 2025 Cited by DOI: 10.1016/j.apsb.2025.06.025 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.93 Å)

Structure validation