9LN5

Crystal structure of P450revI A241L mutant in complex with reveromycin T

Summary for 9LN5

• Entry DOI: 10.2210/pdb9ln5/pdb
• Descriptor: Putative monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (2E,4S,5S,6E,8E)-10-{(2R,3S,6S,8R,9S)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl}-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid, ... (5 entities in total)
• Functional Keywords: cytochrome p450, heme, reveromycin, biosynthesis, oxidoreductase
• Biological source: Streptomyces sp. SN-593
• Total number of polymer chains: 1
• Total formula weight: 46026.19

Authors

Fujiyama, K.,Yong, Y.F.,Takahashi, S. (deposition date: 2025-01-20, release date: 2025-07-02)

• Primary citation: Yong, Y.F.,Liu, S.,Sakai, K.,Fujiyama, K.,Takagi, H.,Futamura, Y.,Shimizu, T.,Osada, H.,Ong, E.B.B.,Takahashi, S.; Biosynthesis of reveromycin derivatives by altering the regioselectivity of cytochrome P450revI; Chem Sci, 2025; DOI: 10.1039/D5SC01355K

Experimental method

X-RAY DIFFRACTION (2.13 Å)