9LL8

Psilocin-bound Serotonin 2A (5-HT2A) receptor-Gi complex

Summary for 9LL8

• Entry DOI: 10.2210/pdb9ll8/pdb
• EMDB information: 63193
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (7 entities in total)
• Functional Keywords: complex, agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 138640.60

Authors

Xu, Z.,Shao, Z.H. (deposition date: 2025-01-17, release date: 2026-01-14, Last modification date: 2026-02-04)

• Primary citation: Xu, Z.,Wang, H.,Yu, J.,Deng, Y.,Tian, X.,Ni, R.,Xia, F.,Yang, L.,Xu, C.,Zhang, L.,Luo, R.,Chen, P.,Zhang, X.,Liu, Y.,Hou, J.,Zhang, M.,Chen, S.,Su, L.,Sun, H.,He, Y.,Chen, D.,Chen, X.,Miao, Z.,Xie, J.,Liu, X.,Zhao, J.,Ke, B.,Tian, X.,Zeng, L.,Zhang, L.,Tang, X.,Yang, S.,Liu, J.,Wang, X.,Yan, W.,Shao, Z.; Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling; Nature, 2026; DOI: 10.1038/s41586-025-10061-7

Experimental method

ELECTRON MICROSCOPY (2.62 Å)