9LIO

Human cGAS catalytic domain bound with XL-3123

This is a non-PDB format compatible entry.

Summary for 9LIO

• Entry DOI: 10.2210/pdb9lio/pdb
• Descriptor: Cyclic GMP-AMP synthase, 2-[bis[1-[4,6-bis(fluoranyl)-1,3-benzothiazol-2-yl]-3-methyl-5-oxidanyl-pyrazol-4-yl]methyl]benzoic acid, ZINC ION, ... (4 entities in total)
• Functional Keywords: cgas, inhibitor, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86982.61

Authors

Zhao, W.F.,Li, M.J.,Xu, Y.C. (deposition date: 2025-01-14, release date: 2025-06-04)

• Primary citation: Zhao, W.F.,Xu, Y.C.; Discovery of novel cGAS inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.92 Å)