9L2D

Structure of SARM1 bound to M1 in the intermediate state 1

Summary for 9L2D

Entry DOI	10.2210/pdb9l2d/pdb
EMDB information	62772
Descriptor	NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate (2 entities in total)
Functional Keywords	nad(+) hydrolase, cell death, apoptosis, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	8
Total formula weight	646459.20
Authors	Huang, Y.,Zhang, J.,Zheng, S.,Wang, X. (deposition date: 2024-12-17, release date: 2025-03-12)
Primary citation	Huang, Y.,Zhang, J.,Zheng, S.,Wang, X. Stepwise Activation of SARM1 by a Biosynthetic NMN mimic To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.83 Å)

Structure validation