9KCC

DNA duplex containing copper-mediated 5-fluorouracil-cytosine base pairs

9KCC の概要

• エントリーDOI: 10.2210/pdb9kcc/pdb
• 分子名称: DNA (5'-D(*GP*GP*AP*CP*CP*CP*(UFP)P*GP*GP*TP*CP*C)-3'), COPPER (II) ION (2 entities in total)
• 機能のキーワード: metal-mediated base pair, copper, 5-fluorouracil, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3706.88

構造登録者

Kondo, J.,Hirabayashi, K.,Torigoe, H.,Adachi, S. (登録日: 2024-11-01, 公開日: 2025-09-10)

主引用文献

Torigoe, H.,Hirabayashi, K.,Adachi, S.,Kondo, J.
Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA.
Dalton Trans, 54:7208-7213, 2025

PubMed Abstract: Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C-Cu-FdU and FdU-Cu-C base pairs.

PubMed: 40265694
DOI: 10.1039/d5dt00619h

実験手法

X-RAY DIFFRACTION (2.31 Å)