9K93

Cryo-EM structure of human signal peptide peptidase like 2A (SPPL2a) in complex with L685,458

Summary for 9K93

• Entry DOI: 10.2210/pdb9k93/pdb
• EMDB information: 62186
• Descriptor: Signal peptide peptidase-like 2A, ~{tert}-butyl ~{N}-[(2~{S},3~{R},5~{R})-6-[[(2~{S})-1-[[(2~{S})-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-3-oxidanyl-6-oxidanylidene-1-phenyl-5-(phenylmethyl)hexan-2-yl]carbamate (2 entities in total)
• Functional Keywords: intramembrane protease, signal peptide peptidase, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 58862.67

Authors

Zhou, R.,Huang, G.,Guo, X.,Wang, J.,Ge, X.,Shi, Y. (deposition date: 2024-10-25, release date: 2025-10-29)

• Primary citation: Zhou, R.,Huang, G.,Guo, X.,Wang, J.,Ge, X.,Shi, Y.; Structural insights into human signal peptide peptidase; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.6 Å)