9JXT

An aldehyde-containing intermediate of SufS in complex with (2R,3R)-3-ethoxycarbonylaziridine-2-carboxylic acid

This is a non-PDB format compatible entry.

Summary for 9JXT

• Entry DOI: 10.2210/pdb9jxt/pdb
• Descriptor: Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, (2~{S})-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-oxidanylidene-propanoic acid, ... (4 entities in total)
• Functional Keywords: cysteine desulfurase, biosynthetic protein
• Biological source: Bacillus subtilis subsp. subtilis str. 168
• Total number of polymer chains: 1
• Total formula weight: 47024.91

Authors

Nakamura, R.,Fujishiro, T. (deposition date: 2024-10-11, release date: 2025-07-16)

• Primary citation: Fujishiro, T.,Otsuka, H.,Nakamura, R.,Fujihara, T.; Discovery of an Aziridine-Based Inhibitor That Targets Cysteine Desulfurase Type II SufS via High-Throughput X-ray Crystallography; Acs Med.Chem.Lett., 2025; DOI: 10.1021/acsmedchemlett.5c00168

Experimental method

X-RAY DIFFRACTION (2.2 Å)