9JR2

Cryo-EM structure of PTH-PTH1R-Gq (upright state)

Summary for 9JR2

• Entry DOI: 10.2210/pdb9jr2/pdb
• EMDB information: 61746
• Descriptor: Guanine nucleotide-binding protein G(q) subunit alpha-1 (miniGq), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: class b gpcrs, gq, pth, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 168860.20

Authors

Sano, F.K.,Hirano, H.,Itoh, Y.,Nureki, O. (deposition date: 2024-09-29, release date: 2024-10-16, Last modification date: 2024-11-06)

• Primary citation: Sano, F.K.,Kobayashi, K.,Kawakami, K.,Akasaka, H.,Kobayashi, T.A.,Tanaka, T.,Okamoto, H.H.,Hirano, H.,Kusakizako, T.,Shihoya, W.,Kise, Y.,Itoh, Y.,Ishitani, R.,Okada, Y.,Inoue, A.,Nureki, O.; Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.8 Å)