9JBG

Cryo-EM structure of the human LYCHOS in complex with lipids in the expanded state

Summary for 9JBG

• Entry DOI: 10.2210/pdb9jbg/pdb
• Related: 9JBE
• EMDB information: 61313
• Descriptor: Lysosomal cholesterol signaling protein, 1,2-Distearoyl-sn-glycerophosphoethanolamine, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ... (5 entities in total)
• Functional Keywords: permease-like domain, gpcr-like domain, cholesterol, mtorc1, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 200176.52

Authors

Yu, S.,Liang, L. (deposition date: 2024-08-27, release date: 2025-07-16)

• Primary citation: Yu, S.,Liang, L.; Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.76 Å)