9JA3

Herpes simplex virus type 1 polymerase machinery in complex with duplex DNA, acyclovir triphosphate and calcium ions

Summary for 9JA3

• Entry DOI: 10.2210/pdb9ja3/pdb
• Related: 9JA2
• EMDB information: 61289
• Descriptor: DNA polymerase, DNA polymerase processivity factor, DNA (27-MER), ... (6 entities in total)
• Functional Keywords: herpes simplex virus type 1, hsv-1, ul30, ul42, dna replication holoenzyme, dna replication machinery, acyclovir triphosphate, dna, calcium, replication
• Biological source: Human herpesvirus 1 (strain 17) (HHV-1, Human herpes simplex virus 1); More
• Total number of polymer chains: 4
• Total formula weight: 206900.36

Authors

Wu, Y.Q.,Chen, X.L.,Jiang, Z.Y.,Li, D.Y.,Zhang, Z.Y.,Dong, C.J. (deposition date: 2024-08-24, release date: 2025-09-03)

• Primary citation: Wu, Y.Q.,Chen, X.L.,Jiang, Z.Y.,Li, D.Y.,Zhang, Z.Y.,Dong, C.J.; Structural basis of herpes simplex type 1 virus DNA polymerase holoenzyme in DNA replication and acyclovir inhibition and proof-reading; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.15 Å)