9IT5

p300 KAT domain in complex with KB528

This is a non-PDB format compatible entry.

Summary for 9IT5

• Entry DOI: 10.2210/pdb9it5/pdb
• Descriptor: Histone acetyltransferase p300, 4-[(2~{S})-1-[[(~{R})-[(3~{S})-7-(1-methylpyrazol-4-yl)-2,3-dihydro-1~{H}-pyrido[2,3-b][1,4]oxazin-3-yl]-phenyl-methyl]amino]propan-2-yl]benzenecarbonitrile, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: kb528, ep300, p300, histone acetyltransferase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 82092.74

Authors

Rahl, P.,Gao, H.,Calderon, Y.,Wang, Z.-F. (deposition date: 2024-07-19, release date: 2025-07-23)

• Primary citation: Lenoir, F.,McKeown, M.,Giorgetti, G.,Kobylarz, M.,Hopkins, T.,Glore, W.,Shum, M.,Calderon, Y.,Carvajal, L.,Mori, K.,Gao, H.,Zhou, M.,Trotter, B.,Dinsmore, C.,Munshi, N.,Lin, C.,Fulciniti, M.,Mariateresa, F.,Rahl, P.; p300 catalytic inhibition selectively targets IRF4 oncogenic activity in multiple myeloma; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)