9HVP
Design, activity and 2.8 Angstroms crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
Summary for 9HVP
Entry DOI | 10.2210/pdb9hvp/pdb |
Related PRD ID | PRD_000256 |
Descriptor | HIV-1 Protease, benzyl [(1R,4S,6S,9R)-4,6-dibenzyl-5-hydroxy-1,9-bis(1-methylethyl)-2,8,11-trioxo-13-phenyl-12-oxa-3,7,10-triazatridec-1-yl]carbamate (3 entities in total) |
Functional Keywords | acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22398.46 |
Authors | Neidhart, D.J.,Erickson, J. (deposition date: 1990-11-06, release date: 1992-04-15, Last modification date: 2024-02-14) |
Primary citation | Erickson, J.,Neidhart, D.J.,VanDrie, J.,Kempf, D.J.,Wang, X.C.,Norbeck, D.W.,Plattner, J.J.,Rittenhouse, J.W.,Turon, M.,Wideburg, N. Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease. Science, 249:527-533, 1990 Cited by PubMed: 2200122PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report