9HPW

Crystal structure of meropenem bound to OXA-57

9HPW の概要

• エントリーDOI: 10.2210/pdb9hpw/pdb
• 分子名称: Beta-lactamase, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
• 機能のキーワード: class-d beta-lactamase complex with a carbapenem, antimicrobial protein
• 由来する生物種: Burkholderia pseudomallei
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27419.01

構造登録者

Bragginton, E.C.,Hinchliffe, P.,Spencer, J. (登録日: 2024-12-16, 公開日: 2025-12-24)

• 主引用文献: Bragginton, E.C.,Colenso, C.K.,Calvopina, K.,Hinchliffe, P.,Shaw, J.M.,Tooke, C.L.,Seng, R.,Chantratita, N.,Schofiled, C.J.,Spencer, J.; Structure and dynamics of Burkholderia pseudomallei OXA-57, a distinctive low efficiency class D beta-lactamase with carbapenem-hydrolyzing activity; To Be Published,

実験手法

X-RAY DIFFRACTION (2.42 Å)