9HCB

The L2C alpha-synuclein fibril in the presence of MODAG-005 (long incubation)

Summary for 9HCB

• Entry DOI: 10.2210/pdb9hcb/pdb
• Related: 9hc6
• EMDB information: 52043
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: alpha-synuclein, fibril, modag-005, pet tracer, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 144761.08

Authors

Frieg, B.,Kim, M.,Griesinger, C.,Schroeder, G.F. (deposition date: 2024-11-08, release date: 2025-11-19, Last modification date: 2026-06-03)

• Primary citation: Kim, M.,Matthes, D.,Frieg, B.,Leonov, A.,Ryazanov, S.,Bleher, D.,Grotegerd, A.K.,Dienemann, C.,Giese, A.,Schroder, G.F.,Becker, S.,Herfert, K.,Groot, B.L.D.,Andreas, L.B.,Griesinger, C.; Structural insight into binding of novel PET tracer MODAG-005 to lipidic alpha-Synuclein fibrils; Biorxiv, 2025; DOI: 10.1101/2025.04.21.649837

Experimental method

ELECTRON MICROSCOPY (2.95 Å)