9GW5

type-I interferon autoantibodies pmab3, pmab19 and pmab14 in complex with Interferon alpha-2

Summary for 9GW5

• Entry DOI: 10.2210/pdb9gw5/pdb
• Related: 9GVL 9GVO
• Descriptor: Interferon alpha-2, type-I interferons autoantibody pamb14 heavy chain, scFv type-I interferons autoantibody pamb03, ... (4 entities in total)
• Functional Keywords: type-i interferon, interferon alpha-2, autoantibody, antigen antibody complex, covid-19 pneumonia, signaling protein, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 111839.28

Authors

Duquerroy, S.,Rey, F.,Mahevas, M.,Chappert, P.,Ahouzi, O. (deposition date: 2024-09-26, release date: 2025-10-08)

• Primary citation: Vanderkerken, M.,Fournier, M.,Dorgham, K.,Bastard, P.,Ahouzi, O.,Duquerroy, S.,Nguyen, N.K.,Broutin, M.,Charlet, M.,Vandenberghe, A.,Bizien, L.,Da Mata-Jardin, O.,Haouz, A.,Belmondo, T.,Hue, S.,Borghesi, A.,Rodriguez-Gallego, C.,Vinh, D.,Andreakos, V.,Haerynck, F.,Halwani, R.,Hammerstrom, T.Q.P.,Bjorkstrom, N.,Strunz, B.,Mogensen, T.,Trouillet, S.,Neven, B.,Levy, R.,Le Voyer, T.,Delmonte, O.,O'Farrelly, C.,Riviere, J.,Amador Borrero, B.,Servettaz, A.,Crickx, E.,Michel, M.,Puel, A.,Abel, L.,Luyt, C.E.,Mathian, A.,Amoura, Z.,weill, J.C.,Casanova, J.L.,Rey, F.A.,Gorochov, G.,Chappert, P.,Mahevas, M.; Temporal and structural insights into type-I interferons autoantibodies in severe COVID-19; To Be Published,

Experimental method

X-RAY DIFFRACTION (4 Å)