9GJ2

Crystal structure of human cathepsin S produced in insect cells in complex with ketoamide 13b

Summary for 9GJ2

• Entry DOI: 10.2210/pdb9gj2/pdb
• Related: 8PRX
• Descriptor: Cathepsin S, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{S})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: cysteine protease, drug target, thiohemiketal, main protease inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 55309.80

Authors

Falke, S.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Reinke, P.Y.A.,Guenther, S.,Turk, D.,Meents, A. (deposition date: 2024-08-20, release date: 2024-09-04, Last modification date: 2024-11-06)

• Primary citation: Falke, S.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Reinke, P.Y.A.,Guenther, S.,Turk, D.,Meents, A.; Crystal structure of human cathepsin S produced in insect cells in complex with ketoamide 13b; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.15 Å)