9GG7

Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS324 peptide and covalent stabilizer 187

9GG7 の概要

• エントリーDOI: 10.2210/pdb9gg7/pdb
• 分子名称: 14-3-3 protein sigma, Isoform Tau-G of Microtubule-associated protein tau, 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl)benzaldehyde, ... (4 entities in total)
• 機能のキーワード: 14-3-3, tau, protein-protein interaction, covalent stabilization, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56841.85

構造登録者

van den Oetelaar, M.C.M.,van de Wijngaart, T.R.,Brunsveld, L.,Ottmann, C. (登録日: 2024-08-13, 公開日: 2025-08-27)

• 主引用文献: van den Oetelaar, M.C.M.,Ravatt, L.,Maqueda Zelaya, F.,Oberheide, A.O.,van de Wijngaart, T.R.,van Veldhuisen, T.W.,van Boxtel, F.M.A.,Verhoef, C.J.A.,Cossar, P.J.,Wegmann, S.,Ottmann, C.,Brunsveld, L.; Modulation of Tau Condensation with 14-3-3/Tau Molecular Glues; To Be Published,

実験手法

X-RAY DIFFRACTION (1.24 Å)