9GET

Crystal structure of CREBBP bromodomain in complex with (R,E)-6-(5-(7-methoxy-3,4-dihydroquinolin-1(2H)-yl)pent-1-en-1-yl)-4-methyl-8-(morpholine-4-carbonyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one

This is a non-PDB format compatible entry.

Summary for 9GET

• Entry DOI: 10.2210/pdb9get/pdb
• Related: 9GEJ
• Descriptor: CREBBP, (4~{R})-6-[(~{E})-5-(7-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)pent-1-enyl]-4-methyl-8-morpholin-4-ylcarbonyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one (3 entities in total)
• Functional Keywords: bromodomain, crebbp, protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 14742.00

Authors

Amann, M.,Boyd, A.,Einsle, O.,Guenther, S.,Monoglu, M.,Conway, S. (deposition date: 2024-08-07, release date: 2025-08-20)

• Primary citation: Amann, M.,Boyd, A.,Einsle, O.,Guenther, S.,Monoglu, M.,Conway, S.; Crystal structure of CREBBP bromodomain in complex with (R,E)-6-(5-(7-methoxy-3,4-dihydroquinolin-1(2H)-yl)pent-1-en-1-yl)-4-methyl-8-(morpholine-4-carbonyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.29 Å)