9GBE

Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound Mutation in Complex with NVL-655

This is a non-PDB format compatible entry.

Summary for 9GBE

• Entry DOI: 10.2210/pdb9gbe/pdb
• Descriptor: ALK tyrosine kinase receptor, NVL-655 (3 entities in total)
• Functional Keywords: alk, tyrosine kinase inhibitor, resistance, nvl-655, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39385.69

Authors

Mente, S.,Horan, J.C. (deposition date: 2024-07-31, release date: 2024-09-18)

• Primary citation: Lin, J.J.,Horan, J.C.,Tangpeerachaikul, A.,Swalduz, A.,Valdivia, A.,Johnson, M.,Besse, B.,Camidge, D.R.,Fujino, T.,Yoda, S.,Nguyen-Phuong, L.,Mizuta, H.,Bigot, L.,Nobre, C.,Lee, J.B.,Yu, M.R.,Mente, S.,Sun, Y.,Kohl, N.E.,Porter, J.R.,Shair, M.D.,Zhu, V.W.,Felip, E.,Cho, B.C.,Friboulet, L.,Hata, A.N.,Pelish, H.E.,Drilon, A.; NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.58 Å)