9G6A

Peptide-Small Molecule Hybrids as Novel Selective Irreversible Cathepsin-K Inhibitors in Primary Osteoclasts and Human Lung Cancer Tissue

This is a non-PDB format compatible entry.

Summary for 9G6A

• Entry DOI: 10.2210/pdb9g6a/pdb
• Related: 6QBS
• Descriptor: Cathepsin K, (2~{S})-4-methyl-~{N}-(2-oxidanylidenepropyl)-2-[[(1~{S})-2,2,2-tris(fluoranyl)-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide, TRIETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: inhibitor complex with human cathepsin k, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 48797.07

Authors

Turk, D.,Loboda, J. (deposition date: 2024-07-18, release date: 2025-07-30)

• Primary citation: Gourag, D.,Loboda, J.; Peptide-Small Molecule Hybrids as Novel Selective Irreversible Cathepsin-K Inhibitors in Primary Osteoclasts and Human Lung Cancer Tissue; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.99 Å)