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9FYP

Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.

Replaces:  8PIC
Summary for 9FYP
Entry DOI10.2210/pdb9fyp/pdb
EMDB information50888
DescriptorAlpha-synuclein, CHLORIDE ION (3 entities in total)
Functional Keywordsamyloid, polymorphism, protein fibril
Biological sourceHomo sapiens (human)
Total number of polymer chains10
Total formula weight145115.61
Authors
Frey, L.,Qureshi, B.M.,Kwiatkowski, W.,Rhyner, D.,Greenwald, J.,Riek, R. (deposition date: 2024-07-03, release date: 2024-07-17, Last modification date: 2024-09-11)
Primary citationFrey, L.,Ghosh, D.,Qureshi, B.M.,Rhyner, D.,Guerrero-Ferreira, R.,Pokharna, A.,Kwiatkowski, W.,Serdiuk, T.,Picotti, P.,Riek, R.,Greenwald, J.
On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Elife, 12:-, 2024
Cited by
PubMed: 39196271
DOI: 10.7554/eLife.93562
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (2.23 Å)
Structure validation

225158

數據於2024-09-18公開中

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