9FXJ

Crystal structure of cobalt(II)-substituted double mutant Y115E Y117E human Glutaminyl Cyclase in complex with PBD-150

Summary for 9FXJ

• Entry DOI: 10.2210/pdb9fxj/pdb
• Related: 9FXG 9FXH 9FXI
• Descriptor: Glutaminyl-peptide cyclotransferase, COBALT (II) ION, 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea, ... (5 entities in total)
• Functional Keywords: human glutaminyl cyclase, acyltransferase, hqc, cobalt ion, pbd-150, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 118110.58

Authors

Tassone, G.,Pozzi, C.,Mangani, S. (deposition date: 2024-07-01, release date: 2024-09-04)

• Primary citation: Tassone, G.,Pozzi, C.,Mangani, S.; Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective.; Int J Mol Sci, 25:-, 2024; PubMed: 39125848; DOI: 10.3390/ijms25158279

Experimental method

X-RAY DIFFRACTION (3.06 Å)