Summary for 9FWG
Entry DOI | 10.2210/pdb9fwg/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, Bomedemstat FAD adduct (3 entities in total) |
Functional Keywords | bomedemstat, epigenetics, histone demethylase, oxidoreductase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 147350.52 |
Authors | |
Primary citation | Jasmine, S.,Mandl, A.,Krueger, T.E.G.,Dalrymple, S.L.,Antony, L.,Dias, J.,Celatka, C.A.,Tapper, A.E.,Kleppe, M.,Kanayama, M.,Jing, Y.,Speranzini, V.,Wang, Y.Z.,Luo, J.,Trock, B.J.,Denmeade, S.R.,Carducci, M.A.,Mattevi, A.,Rienhoff, H.Y.,Isaacs, J.T.,Brennen, W.N. Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. Prostate, 84:909-921, 2024 Cited by PubMed: 38619005DOI: 10.1158/1078-0432.CCR-20-2380 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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