9FVD

Cryo-EM structure of single-layered nucleoprotein-RNA helical assembly from Marburg virus, trimeric repeat unit

9FVD の概要

• エントリーDOI: 10.2210/pdb9fvd/pdb
• EMDBエントリー: 50803
• 分子名称: Nucleoprotein, RNA (5'-R(P*AP*GP*AP*CP*AP*CP*AP*CP*AP*AP*AP*AP*AP*CP*AP*AP*GP*A)-3') (2 entities in total)
• 機能のキーワード: rna-binding protein, viral protein
• 由来する生物種: Marburg virus - Musoke, Kenya, 1980; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 177568.57

構造登録者

Zinzula, L.,Beck, F.,Camasta, M.,Bohn, S.,Liu, C.,Morado, D.,Bracher, A.,Plitzko, J.M.,Baumeister, W. (登録日: 2024-06-26, 公開日: 2024-10-09, 最終更新日: 2024-12-25)

主引用文献

Zinzula, L.,Beck, F.,Camasta, M.,Bohn, S.,Liu, C.,Morado, D.,Bracher, A.,Plitzko, J.M.,Baumeister, W.
Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus.
Nat Commun, 15:10307-10307, 2024

PubMed Abstract: Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix. Our findings illuminate novel RNP interactions and expand knowledge on MARV genome packaging and nucleocapsid assembly, both processes representing attractive targets for the development of antiviral therapeutics against MARV disease.

PubMed: 39604358
DOI: 10.1038/s41467-024-54431-7

実験手法

ELECTRON MICROSCOPY (3.2 Å)