9FOF

Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 2)

Summary for 9FOF

• Entry DOI: 10.2210/pdb9fof/pdb
• EMDB information: 50621
• Descriptor: TAR DNA-binding protein 43, Annexin A11 (2 entities in total)
• Functional Keywords: tdp-43, anxa11, amyloid, heteromeric amyloid, ftld-tdp, neurodegeneration, dementia, brain, protein filament, protein fibril
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 60222.11

Authors

Arseni, D.,Ryskeldi-Falcon, B. (deposition date: 2024-06-11, release date: 2024-07-24)

• Primary citation: Arseni, D.,Nonaka, T.,Jacobsen, M.H.,Murzin, A.G.,Cracco, L.,Peak-Chew, S.Y.,Garringer, H.J.,Kawakami, I.,Suzuki, H.,Onaya, M.,Saito, Y.,Murayama, S.,Geula, C.,Vidal, R.,Newell, K.L.,Mesulam, M.,Ghetti, B.,Hasegawa, M.,Ryskeldi-Falcon, B.; Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C.; Biorxiv, 2024; PubMed: 38979278; DOI: 10.1101/2024.06.25.600403

Experimental method

ELECTRON MICROSCOPY (2.9 Å)