9FMM

Structure of human ACE2 in complex with a fluorinated small molecule inhibitor

This is a non-PDB format compatible entry.

Summary for 9FMM

• Entry DOI: 10.2210/pdb9fmm/pdb
• Descriptor: Angiotensin-converting enzyme 2, (2~{S})-2-[[(2~{S})-3-[3-[(3-chloranyl-5-fluoranyl-phenyl)methyl]imidazol-4-yl]-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-4-methyl-pentanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: enzyme, peptidase, sars-cov-2 receptor, renin-angiotensin-aldosterone system, peptide binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 172309.62

Authors

Benoit, R.B.,Rodrigues, M.J.,Wieser, M.M. (deposition date: 2024-06-06, release date: 2024-07-17)

• Primary citation: Wang, J.,Beyer, D.,Vaccarin, C.,He, Y.,Tanriver, M.,Benoit, R.,Deupi, X.,Mu, L.,Bode, J.W.,Schibli, R.,Mueller, C.; Development of radiofluorinated MLN-4760 derivatives for PET imaging of the SARS-CoV-2 entry receptor ACE2; European Journal of Nuclear Medicine and Molecular Imaging, 2024

Experimental method

X-RAY DIFFRACTION (2.5 Å)