9FMM

Structure of human ACE2 in complex with a fluorinated small molecule inhibitor

これはPDB形式変換不可エントリーです。

9FMM の概要

• エントリーDOI: 10.2210/pdb9fmm/pdb
• 分子名称: Angiotensin-converting enzyme 2, (2~{S})-2-[[(2~{S})-3-[3-[(3-chloranyl-5-fluoranyl-phenyl)methyl]imidazol-4-yl]-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-4-methyl-pentanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: enzyme, peptidase, sars-cov-2 receptor, renin-angiotensin-aldosterone system, peptide binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 172309.62

構造登録者

Benoit, R.B.,Rodrigues, M.J.,Wieser, M.M. (登録日: 2024-06-06, 公開日: 2024-07-17, 最終更新日: 2024-12-04)

主引用文献

Wang, J.,Beyer, D.,Vaccarin, C.,He, Y.,Tanriver, M.,Benoit, R.,Deupi, X.,Mu, L.,Bode, J.W.,Schibli, R.,Muller, C.
Development of radiofluorinated MLN-4760 derivatives for PET imaging of the SARS-CoV-2 entry receptor ACE2.
Eur J Nucl Med Mol Imaging, 52:9-21, 2024

PubMed Abstract: The angiotensin converting enzyme 2 (ACE2) plays a regulatory role in the cardiovascular system and serves SARS-CoV-2 as an entry receptor. The aim of this study was to synthesize and evaluate radiofluorinated derivatives of the ACE2 inhibitor MLN-4760. [F]F-MLN-4760 and [F]F-Aza-MLN-4760 were demonstrated to be suitable for non-invasive imaging of ACE2, potentially enabling a better understanding of its expression dynamics.

PubMed: 39066808
DOI: 10.1007/s00259-024-06831-6

実験手法

X-RAY DIFFRACTION (2.5 Å)