9FBL

Structure of human protein kinase CK2 catalytic subunit (CK2alpha, CSNK2A1 gene product) in complex with the cyclic peptidomimetic compound 15 discovered by high-throughput screening

これはPDB形式変換不可エントリーです。

9FBL の概要

• エントリーDOI: 10.2210/pdb9fbl/pdb
• 分子名称: Casein kinase II subunit alpha, Cyclic peptidomimetic compound FMP35, NICOTINIC ACID, ... (6 entities in total)
• 機能のキーワード: human protein kinase ck2 catalytic subunit alpha, csnk2a1 gene product, inhibition of ck2alpha/ck2beta subunit interaction, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 128899.04

構造登録者

Werner, C.,Niefind, K.,Eimermacher, S.,Pietsch, M.,Lindenblatt, D. (登録日: 2024-05-14, 公開日: 2025-06-11, 最終更新日: 2026-07-01)

• 主引用文献: Werner, C.,Eimermacher, S.,Lauwers, M.,Lindenblatt, D.,Seymen, E.,Kulko, E.,Klein, L.,Steinkruger, M.,Baumann, R.,Salamon, S.,Fried, C.,Fischer, D.,Oder, A.,Neuenschwander, M.,Goetz, C.,Niefind, K.,Pietsch, M.; Discovery and characterization of a novel class of cyclic peptidic compounds inhibiting the subunit interaction of the protein kinase CK2 alpha 2 beta 2 holoenzyme; Rsc Chem Biol, 2026; DOI: 10.1039/D6CB00095A

実験手法

X-RAY DIFFRACTION (2.18 Å)