9F8G

Photostatin (photoswitchable azo-combretastatin) Z-PST27 bound to tubulin-DARPin D1 complex

This is a non-PDB format compatible entry.

Summary for 9F8G

• Entry DOI: 10.2210/pdb9f8g/pdb
• Descriptor: Tubulin alpha-1B chain, Tubulin beta-2B chain, Designed Ankyrin Repeat Protein (DARPIN) D1, ... (8 entities in total)
• Functional Keywords: tubulin polymerisation inhibitor, microtubule dynamics, antimitotics, photopharmacology, photoswitch, sensitisation, cell cycle
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 3
• Total formula weight: 119706.20

Authors

Wranik, M.,Steinmetz, M.O. (deposition date: 2024-05-06, release date: 2024-09-04)

• Primary citation: Reynders, M.,Garscia, M.,Muller-Deku, A.,Wranik, M.,Krauskopf, K.,de la Osa de la Rosa, L.,Schaffer, K.,Jotten, A.,Rode, A.,Stierle, V.,Kraus, Y.,Baumgartner, B.,Ali, A.,Bubeneck, A.,Seal, T.,Steinmetz, M.O.,Paulitschke, P.,Thorn-Seshold, O.; A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol.; Chem Sci, 15:12301-12309, 2024; PubMed: 39118608; DOI: 10.1039/d4sc03072a

Experimental method

X-RAY DIFFRACTION (2.2 Å)