9F6X
Human transforming growth factor b type I receptor in complex with kinase inhibitor SB505124
This is a non-PDB format compatible entry.
Summary for 9F6X
| Entry DOI | 10.2210/pdb9f6x/pdb |
| Descriptor | TGF-beta receptor type-1, 2-[5-(1,3-benzodioxol-5-yl)-2-~{tert}-butyl-1~{H}-imidazol-4-yl]-6-methyl-pyridine, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | tgf-beta receptor type 1 in complex with sb505124, transferase |
| Biological source | Homo sapiens |
| Total number of polymer chains | 1 |
| Total formula weight | 35085.26 |
| Authors | Rodriguez Buitrago, J.A.,Landstrom, M.,Wolf-Watz, M. (deposition date: 2024-05-02, release date: 2024-12-25) |
| Primary citation | Rodriguez Buitrago, J.A.,Landstrom, M.,Wolf-Watz, M. Human transforming growth factor beta type I receptor in complex with kinase inhibitor SB505124. Acta Crystallogr.,Sect.F, 80:314-319, 2024 Cited by PubMed Abstract: The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in complex with the competitive inhibitor SB505124 is presented. The study provides insights into the structure and function of TβR1 in complex with SB505124, and as such offers molecular-level understanding of the inhibition of this critical signalling pathway. The potential of SB505124 as an avenue for therapy in cancer treatment is discussed on basis of the results. PubMed: 39441620DOI: 10.1107/S2053230X24010094 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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