9F6X

Human transforming growth factor b type I receptor in complex with kinase inhibitor SB505124

これはPDB形式変換不可エントリーです。

9F6X の概要

• エントリーDOI: 10.2210/pdb9f6x/pdb
• 分子名称: TGF-beta receptor type-1, 2-[5-(1,3-benzodioxol-5-yl)-2-~{tert}-butyl-1~{H}-imidazol-4-yl]-6-methyl-pyridine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: tgf-beta receptor type 1 in complex with sb505124, transferase
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35085.26

構造登録者

Rodriguez Buitrago, J.A.,Landstrom, M.,Wolf-Watz, M. (登録日: 2024-05-02, 公開日: 2024-12-25)

主引用文献

Rodriguez Buitrago, J.A.,Landstrom, M.,Wolf-Watz, M.
Human transforming growth factor beta type I receptor in complex with kinase inhibitor SB505124.
Acta Crystallogr.,Sect.F, 80:314-319, 2024

PubMed Abstract: The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in complex with the competitive inhibitor SB505124 is presented. The study provides insights into the structure and function of TβR1 in complex with SB505124, and as such offers molecular-level understanding of the inhibition of this critical signalling pathway. The potential of SB505124 as an avenue for therapy in cancer treatment is discussed on basis of the results.

PubMed: 39441620
DOI: 10.1107/S2053230X24010094

実験手法

X-RAY DIFFRACTION (2.68 Å)