9F1K

First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30

これはPDB形式変換不可エントリーです。

9F1K の概要

• エントリーDOI: 10.2210/pdb9f1k/pdb
• 分子名称: Bromodomain-containing protein 4, 2-[4-[2-[2-[2-[4-[3-(dimethylamino)propoxy]phenyl]ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]ethyl]piperazin-1-yl]-N-(2-methoxyethyl)ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, epigenetic drugs, inhibitor, protacs, gene regulation
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15807.28

構造登録者

Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (登録日: 2024-04-19, 公開日: 2024-09-11)

• 主引用文献: Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC); First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30; to be published,

実験手法

X-RAY DIFFRACTION (1.61 Å)