9F1J

First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 14

This is a non-PDB format compatible entry.

Summary for 9F1J

• Entry DOI: 10.2210/pdb9f1j/pdb
• Descriptor: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-[2-[2-[2-[2-[2-[2-[2,6-bis(oxidanylidene)piperidin-3-yl]-1,3-bis(oxidanylidene)isoindol-4-yl]oxyethanoylamino]ethoxy]ethoxy]ethoxy]ethyl]-4-[4-[2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]ethyl]phenoxy]butanamide, ... (4 entities in total)
• Functional Keywords: bromodomain, epigenetic drugs, inhibitor, protacs, thalidomide, gene regulation
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 16157.56

Authors

Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2024-04-19, release date: 2024-09-11)

• Primary citation: Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC); First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 14; to be published,

Experimental method

X-RAY DIFFRACTION (1.13003035503 Å)