9ERY
Co-crystal strucutre of PD-L1 with low molecular weight inhibitor
Summary for 9ERY
Entry DOI | 10.2210/pdb9ery/pdb |
Descriptor | Programmed cell death 1 ligand 1, 5-[[5-[[2-[bis(fluoranyl)methyl]-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]methoxy]-2-[(2-hydroxyethylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile, SULFATE ION, ... (4 entities in total) |
Functional Keywords | pd-l1, inhibitor, immunotheraphy, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 30577.82 |
Authors | Plewka, J.,Magiera-Mularz, K.,Zhang, W. (deposition date: 2024-03-25, release date: 2024-07-24, Last modification date: 2024-07-31) |
Primary citation | Zhang, F.,Zhang, H.,Zhou, S.,Plewka, J.,Wang, M.,Sun, S.,Wu, C.,Yu, Q.,Zhu, M.,Awadasseid, A.,Wu, Y.,Magiera-Mularz, K.,Zhang, W. Design, synthesis, and evaluation of antitumor activity of 2-arylmethoxy-4-(2-fluoromethyl-biphenyl-3-ylmethoxy) benzylamine derivatives as PD-1/PD-l1 inhibitors. Eur.J.Med.Chem., 276:116683-116683, 2024 Cited by PubMed: 39032403DOI: 10.1016/j.ejmech.2024.116683 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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