9ERN
CTE type II tau filament from vacuolar tauopathy
Summary for 9ERN
| Entry DOI | 10.2210/pdb9ern/pdb |
| Related | 9ERM |
| EMDB information | 19927 |
| Descriptor | Microtubule-associated protein tau (1 entity in total) |
| Functional Keywords | tau filament, cte type ii, vacuolar tauopathy, protein fibril |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 6 |
| Total formula weight | 275519.23 |
| Authors | |
| Primary citation | Qi, C.,Kobayashi, R.,Kawakatsu, S.,Kametani, F.,Scheres, S.H.W.,Goedert, M.,Hasegawa, M. Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G. Acta Neuropathol, 147:86-86, 2024 Cited by PubMed Abstract: Dominantly inherited mutation D395G in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of behavioural-variant frontotemporal dementia, with marked vacuolation and abundant filamentous tau inclusions made of all six brain isoforms. Here we report that tau inclusions were concentrated in layers II/III of the frontotemporal cortex in a case of vacuolar tauopathy. By electron cryomicroscopy, tau filaments had the chronic traumatic encephalopathy (CTE) fold. Tau inclusions of vacuolar tauopathy share this cortical location and the tau fold with CTE, subacute sclerosing panencephalitis and amyotrophic lateral sclerosis/parkinsonism-dementia complex, which are believed to be environmentally induced. Vacuolar tauopathy is the first inherited disease with the CTE tau fold. PubMed: 38758288DOI: 10.1007/s00401-024-02741-x PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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