9EM1

Human pyridoxal phosphatase in complex with 7,8-dihydroxyflavone and phosphate

Summary for 9EM1

Entry DOI	10.2210/pdb9em1/pdb
Descriptor	Chronophin, MAGNESIUM ION, 7,8-bis(oxidanyl)-2-phenyl-chromen-4-one, ... (6 entities in total)
Functional Keywords	inhibitor, pdxp, 7 8-dihydroxyflavone, flavone, haloacid dehalogenase type hydrolases, had, phosphatase, chronophin, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32298.72
Authors	Brenner, M.,Gohla, A.,Schindelin, H. (deposition date: 2024-03-07, release date: 2024-06-12, Last modification date: 2024-06-26)
Primary citation	Brenner, M.,Zink, C.,Witzinger, L.,Keller, A.,Hadamek, K.,Bothe, S.,Neuenschwander, M.,Villmann, C.,von Kries, J.P.,Schindelin, H.,Jeanclos, E.,Gohla, A. 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase. Elife, 13:-, 2024 Cited by PubMed: 38856179 DOI: 10.7554/eLife.93094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation