9EFC

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with TO-588

This is a non-PDB format compatible entry.

Summary for 9EFC

• Entry DOI: 10.2210/pdb9efc/pdb
• Descriptor: Hdac6 protein, N-hydroxy-4-({(methanesulfonyl)[(pyridin-3-yl)methyl]amino}methyl)benzamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: potassium ion binding, alkali metal ion binding, ion binding, cation binding, metal ion binding, catalytic activity, hydrolase activity, deacetylase activity, protein deacetylase activity, acting on a protein, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, tubulin deacetylase activity, zinc ion binding, transition metal ion binding, metal binding protein
• Biological source: Danio rerio (zebrafish)
• Total number of polymer chains: 2
• Total formula weight: 80582.07

Authors

Erdogan, F.,Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2024-11-20, release date: 2024-12-04)

• Primary citation: Olaoye, O.,Erdogan, F.,Gunning, P.T.; Bisected Cap Group Modifications Provides Basis for Improved Pharmacokinetics of HDAC Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.26 Å)