9E7M の概要
| エントリーDOI | 10.2210/pdb9e7m/pdb |
| EMDBエントリー | 47685 |
| 分子名称 | Tape measure protein, Tail tip assembly protein I, Tip attachment protein J, ... (9 entities in total) |
| 機能のキーワード | bacteriophage, tail tip complex, viral protein |
| 由来する生物種 | Escherichia phage Lambda 詳細 |
| タンパク質・核酸の鎖数 | 36 |
| 化学式量合計 | 689336.21 |
| 構造登録者 | |
| 主引用文献 | Yu, H.,Wang, C.,Yue, J.,Guo, W.,Molineux, I.J.,Liu, J. Structural basis of bacteriophage Ur-lambda infection initiation. Sci Adv, 11:eadw7914-eadw7914, 2025 Cited by PubMed Abstract: Bacteriophages must recognize host receptors and penetrate the host cell envelope to initiate infection. How the classic phage λ initiates infection is not yet understood. Here, we combine cryo-electron microscopy and tomography to visualize infection initiation by Ur-λ, the original λ isolate that uses side fibers to adsorb rapidly to . We determine the structure of Ur-λ, resolving the full-length central and side fibers, thus providing a structural basis for host recognition. We show that Ur-λ contains six copies of its tape measure protein. We capture intermediates of the tail tip complex during infection initiation, revealing how extensive conformational changes enable adsorption, and visualize the trans-envelope channel required for genome ejection. PubMed: 41237242DOI: 10.1126/sciadv.adw7914 主引用文献が同じPDBエントリー |
| 実験手法 | ELECTRON MICROSCOPY (3.37 Å) |
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