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9E7M

In situ cryoEM structure of bacteriophage Ur-lambda tail tip complex

これはPDB形式変換不可エントリーです。
9E7M の概要
エントリーDOI10.2210/pdb9e7m/pdb
EMDBエントリー47685
分子名称Tape measure protein, Tail tip assembly protein I, Tip attachment protein J, ... (9 entities in total)
機能のキーワードbacteriophage, tail tip complex, viral protein
由来する生物種Escherichia phage Lambda
詳細
タンパク質・核酸の鎖数36
化学式量合計689336.21
構造登録者
Yu, H.,Liu, J.,Molineux, I.J. (登録日: 2024-11-03, 公開日: 2025-11-05, 最終更新日: 2025-11-26)
主引用文献Yu, H.,Wang, C.,Yue, J.,Guo, W.,Molineux, I.J.,Liu, J.
Structural basis of bacteriophage Ur-lambda infection initiation.
Sci Adv, 11:eadw7914-eadw7914, 2025
Cited by
PubMed Abstract: Bacteriophages must recognize host receptors and penetrate the host cell envelope to initiate infection. How the classic phage λ initiates infection is not yet understood. Here, we combine cryo-electron microscopy and tomography to visualize infection initiation by Ur-λ, the original λ isolate that uses side fibers to adsorb rapidly to . We determine the structure of Ur-λ, resolving the full-length central and side fibers, thus providing a structural basis for host recognition. We show that Ur-λ contains six copies of its tape measure protein. We capture intermediates of the tail tip complex during infection initiation, revealing how extensive conformational changes enable adsorption, and visualize the trans-envelope channel required for genome ejection.
PubMed: 41237242
DOI: 10.1126/sciadv.adw7914
主引用文献が同じPDBエントリー
実験手法
ELECTRON MICROSCOPY (3.37 Å)
構造検証レポート
Validation report summary of 9e7m
検証レポート(詳細版)ダウンロードをダウンロード

248636

件を2026-02-04に公開中

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