9E6C

Octopus sensory receptor CRT1 in complex with H3C

これはPDB形式変換不可エントリーです。

9E6C の概要

• エントリーDOI: 10.2210/pdb9e6c/pdb
• EMDBエントリー: 47555
• 分子名称: Chemotactile receptor CRT1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1-methyl-9H-pyrido[3,4-b]indole-3-carboxylic acid (3 entities in total)
• 機能のキーワード: complex, membrane protein
• 由来する生物種: Octopus bimaculoides (California two-spot octopus)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 242226.63

構造登録者

Jiang, H.,Hibbs, R.E. (登録日: 2024-10-29, 公開日: 2025-07-09)

主引用文献

Sepela, R.J.,Jiang, H.,Shin, Y.H.,Hautala, T.L.,Clardy, J.,Hibbs, R.E.,Bellono, N.W.
Environmental microbiomes drive chemotactile sensation in octopus.
Cell, 2025

PubMed Abstract: Microbial communities coat nearly every surface in the environment and have co-existed with animals throughout evolution. Whether animals exploit omnipresent microbial cues to navigate their surroundings is not well understood. Octopuses use "taste-by-touch" chemotactile receptors (CRs) to explore the seafloor, but how they distinguish meaningful surfaces from the rocks and crevices they encounter is unknown. Here, we report that secreted signals from microbiomes of ecologically relevant surfaces activate CRs to guide octopus behavior. Distinct molecules isolated from individual bacterial strains located on prey or eggs bind single CRs in subtly different structural conformations to elicit specific mechanisms of receptor activation, ion permeation and signal transduction, and maternal care and predation behavior. Thus, microbiomes on ecological surfaces act at the level of primary sensory receptors to inform behavior. Our study demonstrates that uncovering interkingdom interactions is essential to understanding how animal sensory systems evolved in a microbe-rich world.

PubMed: 40532695
DOI: 10.1016/j.cell.2025.05.033

実験手法

ELECTRON MICROSCOPY (3.04 Å)