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9E41

Asymmetric unit of yPOWV

Summary for 9E41
Entry DOI10.2210/pdb9e41/pdb
EMDB information47497
DescriptorE glycoprotein, Membrane Protei, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordsviral protein
Biological sourceDeer tick virus
More
Total number of polymer chains6
Total formula weight193464.69
Authors
Das, S.,Hafenstein, S. (deposition date: 2024-10-24, release date: 2025-07-16, Last modification date: 2025-07-23)
Primary citationDas, S.,Narayanan, A.,Wang, A.,Moustafa, I.M.,Cho, S.H.,Mitzel, D.,Jose, J.,Hafenstein, S.L.
Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus.
Sci Adv, 11:eadw7700-eadw7700, 2025
Cited by
PubMed Abstract: Powassan virus (POWV) is an emerging tick-borne flavivirus for which no vaccine or antiviral treatment exists. The incidence of human infections of POWV in North America has been increasing because of the expanding distribution of the tick vector that transmits POWV to humans. To mitigate the dangers of handling a risk group 3 human pathogen, a chimeric virus was constructed from the genetic backbone of a yellow fever virus vaccine strain 17D (YFV-17D) and the external structural proteins of POWV lineage II. The chimera had a comparable phenotype as POWV. The atomic resolution of yellow fever virus-Powassan virus chimera (yPOWV) structure was built without ambiguity, revealing surface glycans and lipid pocket factors. The similarity to other flavivirus structures and the phenotype similar to YFV-17D suggest that there could be future potential as a vaccine candidate.
PubMed: 40632869
DOI: 10.1126/sciadv.adw7700
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (2.83 Å)
Structure validation

239149

건을2025-07-23부터공개중

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