9D4B

Discovery of SMD-3236, a Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers

This is a non-PDB format compatible entry.

Summary for 9D4B

• Entry DOI: 10.2210/pdb9d4b/pdb
• Descriptor: von Hippel-Lindau disease tumor suppressor, Elongin-B, Elongin-C, ... (5 entities in total)
• Functional Keywords: cancer, protein degrader, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 113366.83

Authors

Strickland, C. (deposition date: 2024-08-12, release date: 2025-08-20)

• Primary citation: Strickland, C.; Discovery of SMD-3236, a Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.3 Å)