9D1X

Crystal structure of FGFR3 bound to indazole inhibitor

This is a non-PDB format compatible entry.

Summary for 9D1X

• Entry DOI: 10.2210/pdb9d1x/pdb
• Descriptor: Fibroblast growth factor receptor 3, (3P)-N-(2,6-dimethylphenyl)-6-methoxy-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-5-carboxamide, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: fibroblast growth factor receptor 3, inhibitor, cell cycle
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34177.20

Authors

Postel, S.,Johnson, Z.L. (deposition date: 2024-08-08, release date: 2025-06-25)

• Primary citation: Damm, W.,Dajnowicz, S.,Ghoreishi, D.,Yu, Y.,Ganeshan, K.,Madin, O.,Rudshteyn, B.,Hu, R.,Wu, M.,Shang, Y.,Albanese, S.,Zou, Y.,Ye, M.,Johnson, Z.,Trzoss, M.,Rafi, S.,Kapilashrami, K.,Saleh, N.,Ghanakota, P.,Zhang, Y.,Sampson, J.,Chen, W.,Wang, L.,Dahlgren, M.,Russell, E.,Leffler, A.,Abel, R.,Friesner, R.,Harder, E.; OPLS5: Addition of Polarizability and Improved Treatment of Metals; Chemrxiv, 2024; DOI: 10.26434/chemrxiv-2024-2svr7

Experimental method

X-RAY DIFFRACTION (1.6 Å)