9CYQ
Crystal structure of Q78R mutant human PTP1B (PTPN1) at room temperature (298 K)
Summary for 9CYQ
| Entry DOI | 10.2210/pdb9cyq/pdb |
| Descriptor | Tyrosine-protein phosphatase non-receptor type 1, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | ptp1b, phosphatase, allostery, ptp, hydrolase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 37497.14 |
| Authors | Ebrahim, A.,Perdikari, A.,Woods, V.A.,Lawler, K.,Bounds, R.,Singh, N.I.,Mehlman, T.,Riley, B.T.,Sharma, S.,Morris, J.W.,Keogh, J.M.,Henning, E.,Smith, M.,Farooqi, I.S.,Keedy, D.A. (deposition date: 2024-08-02, release date: 2024-08-21) |
| Primary citation | Perdikari, A.,Woods, V.,Ebrahim, A.,Lawler, K.,Bounds, R.,Singh, N.,Mehlman, T.,Riley, B.,Sharma, S.,Morris, J.,Keogh, J.,Henning, E.,Smith, M.,Farooqi, I.,Keedy, D. Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy Biorxiv, 2024 Cited by DOI: 10.1101/2024.08.05.603709PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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